Anti-Inflammatory Effect of IL-37b in Children with Allergic Rhinitis

Anti-Inflammatory Effect of IL-37b in Children with Allergic Rhinitis

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Background.Interleukin-37 (IL-37), a newly described member of IL-1family, functioned as a fundamental inhibitor of innate inflammatory and immune responses, especially its isoform IL-37b.Objective.This study was undertaken to evaluate the expression and regulation of IL-37b in children with allergic rhinitis (AR).

Methods.Forty children with AR and twenty-five normal controls were included.The relationship between IL-37b and Th1/2 cytokines production in serum and nasal lavage was examined by enzyme-linked immunosorbent assay CHEDDAR STYLE SLICES (ELISA).Peripheral blood mononuclear cells (PBMCs) were purified for in vitro regulation experiment of IL-37b.

Intranasal mometasone furoate was given in AR children and IL-37b change after one-month treatment was detected using ELISA.Results.We observed significantly decreased IL-37b expression levels in both serum and nasal lavage compared to controls.IL-37b was negatively correlated with Th2 cytokines.

Our results also showed that IL-37b downregulated Th2 cytokine expressed by PBMCs and Ring Toss this modulation was through mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathway.We also found that intranasal mometasone furoate therapy can promote nasal IL-37b expression.Conclusion.IL-37b may be involved in Th2 cytokine regulation in AR and its expression was related to the efficacy of intranasal steroid therapy.